It all depends on how much you use the Twiddler. Let's say it has 1000 complete discharges in its life time. The more you use it, the more discharges you use. If you charge from 50% back to 100% that would be considered a 1/2 complete discharge.
So being miserly with your usage will extend battery life not only during the current charge cycle but also the the entire lifetime of the battery.